Buy Dapoxetine Online

Dapoxetine is a short acting selective serotonin reuptake inhibitor (SSRI) used specifically for the treatment of premature ejaculation in men aged between 18 and 64 years. This medicine should not be taken by men who are not diagnosed with premature ejaculation (PE).

Dapoxetine is a selective serotonin reuptake inhibitor that demonstrated efficiency in thousands of male patients with premature ejaculation problem. It increases the levels of serotonin in the brain enhancing the patient’s control over ejaculation and having other beneficial effects on sexual life.

Before Taking Dapoxetine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking dapoxetine it is important that your doctor knows:

• If you have a tendency to faint.
• If you have a heart condition.
• If you have a bleeding or clotting disorder.
• If you have epilepsy.
• If you have ever had a mental health problem causing ‘high’ or ‘low’ moods, such as bipolar disorder, depression or mania.
• If you have increased pressure in your eye, a condition called glaucoma.
• If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.
• If you have ever had an allergic reaction to a medicine.
• If you are taking any other medicines. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines.

Pharmacokinetics

Absorption

• Dapoxetine is a white powder substance and water- insoluble. Taken 1–3 hours before sexual activity, it is rapidly absorbed in the body. Its maximum plasma concentration (Cmax) is reached 1–2 hours after oral administration. The Cmax and AUC (Area Under the plasma vs. time Curve) are dose dependent. The Cmax and Tm (time needed to obtain the maximum plasma concentration) after single doses of dapoxetine 30 mg and 60 mg are 297 and 498 ng/mL at 1.01 and 1.27 hours respectively. A high fat meal does reduce the Cmax slightly, but it is insignificant. In fact, food doesn’t alter dapoxetine pharmacokinetics. Dapoxetine can be taken with or without food.

Distribution

• Dapoxetine is absorbed and distributed rapidly in the body. Greater than 99% of dapoxetine is bound to the plasma protein. The mean steady state volume is 162 L. Its initial half-life is 1.31 hours (30 mg dose) and 1.42 hours (60 mg dose,) and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose).

Metabolism

• Dapoxetine is metabolized extensively in the liver and kidney by multiple enzymes such as CYP2D6, CYP3A4, and flavin monooxygenase 1 (FMO1). The major product at the end of the metabolic pathway is circulating dapoxetine N-oxide, which is a weak SSRI and contributes no clinical effect. The other products presented less than 3% in the plasma are desmethyldapoxetine and didesmethydapoxetine. Desmethyldapoxetine is approximately equipotent to dapoxetine.

Excretion

• The metabolites of dapoxetine are eliminated rapidly in the urine with a terminal half-life of 18.7 and 21.9 hours for a single dose of 30 mg and 60 mg respectively.

Brand Name

• Poxet 30mg
• Poxet 60mg
• Poxet 90mg
• Duratia 90mg
• Duratia 60mg
• Duratia 30mg
• Vriligy 60mg

Side Effects

• Dizziness and lightheadedness
• Nervousness and confusion
• Excessive sweating
• Headache
• Diarrhea
• Sleeplessness
• Decreased libido
• Blurred vision
• Ringing or buzzing in the ears
• Fast/irregular heart beat
• Increase in blood pressure
• Excessive tiredness
• Dry mouth

Safety And Tolerability

Cardiovascular safety

• The cardiovascular safety profile of dapoxetine has been studied extensively during the drug development. Phase I trials showed that dapoxetine had neither clinical significant electrocardiographic effects nor delayed repolarization effects, with dosing up to four-fold greater than the maximum recommended dosage which is 60 mg. Phase III studies in men with PE showed a safety and well tolerate profile of dapoxetine with dosing of 30 and 60 mg. There is no cardiovascular adverse had been found.

Neurocognitive safety

• Studies of SSRIs in patients with major psychiatric disorders prove that SSRIs are potentially associated with certain neurocognitive adverse effects such as anxiety, akathisia, hypomania, changes in mood, or suicidal thought. However, there is no study on the effects of SSRIs in men with PE. McMahon’s study in 2012 showed that dapoxetine has no effect on mood and is not associated with anxiety or suicidality.

Withdrawal syndrome

• The incidence of antidepressant discontinuation syndrome symptoms in men using dapoxetine to treat premature ejaculation has been described by reviewers as low or no different from the incidence of such symptoms in men withdrawn from placebo treatment. The lack of chronic serotonergic stimulation with on-demand dapoxetine minimizes the potentiation action of serotonin at synaptic cleft, thus decreasing the risk of DESS.

Warnings

• Pregnancy – This medicine is not recommended for use in women.
• Breast-feeding – This medicine is not recommended for use in women.

General warnings

• Other medicines – Since this medicine interacts with many other medicines and may cause serious adverse effects, it is advised that you should inform the doctor about all your medicines including herbs and supplements before beginning treatment with this medicine.
• Use in healthy men – This medicine should not be used by men who have not been diagnosed clinically with premature ejaculation. Safety and efficacy of this medicine for delaying ejaculation in healthy men is not established and hence self-administration is not recommended.
• Use with alcohol and recreational drugs – This medicine should not be used along with alcohol or any other recreational drugs since the risk of serious adverse effects is significantly high.
• Proper diagnosis – It is advised to take this medicine only after a proper diagnosis has been made. This medicine should not be used for other forms of sexual dysfunctions.
• Orthostatic hypotension – Use of this medicine may cause a fall in blood pressure, especially while getting up from a sitting or a lying position, leading to lightheadedness, fainting, and falling. An appropriate clinical examination is advised before initiating the uptake of this medicine. It is advised that you get up slowly from a sitting or a lying position to avoid these side effects during treatment with this medicine. Report any such symptoms to the doctor immediately.
• Use in children – This medicine is not recommended for use in patients less than 18 years of age.
• Bleeding disorders – This medicine should be used with caution in patients suffering from an active bleeding disorder due to the increased risk of excessive bleeding.
• Seizures – This medicine should be used with caution in patients suffering from a seizure disorder due to the increased risk of worsening of the patient’s symptoms. Any seizure episodes should be reported to the doctor on priority. Therapy with the medicine may be discontinued based on the clinical condition of the patient.
• Lactose intolerance – This medicine contains lactose and hence it should not be used by patients suffering from a genetic abnormality making them lactose intolerant.
• Dizziness and fainiting – Use of this medicine may cause recurring episodes of dizziness and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery during treatment with this medicine.

Important Safety Information:

• Dapoxetine may cause dizziness, drowsiness, fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Dapoxetine with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
• Dapoxetine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Patients with heart problems who take Dapoxetine may be at increased risk for heart-related side effects, including heart attack or stroke. Symptoms of a heart attack may include chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes. Symptoms of a stroke may include confusion, vision or speech changes, one-sided weakness, or fainting. Contact your doctor or seek medical attention right away if you experience these symptoms.
• Dapoxetine may rarely cause a prolonged (eg, more than 4 hours) or painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if you have an erection that lasts more than 4 hours.
• Dapoxetine does not stop the spread of HIV or other sexually transmitted diseases (STDs) to others through sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection or an STD.
• Dapoxetine will not prevent pregnancy. If your partner may become pregnant and you wish to avoid pregnancy, be sure to use an effective form of birth control.
• Dapoxetinemay uncommonly cause mild, temporary vision changes (eg, blurred vision, sensitivity to light, blue/green color tint to vision). Contact your doctor if vision changes persist or are severe.
• Do not use other medicines or treatments for ED while you are taking Dapoxetine without first checking with your doctor.
• Use Dapoxetine with caution in the elderly; they may be more sensitive to its effects.
• Dapoxetine is not recommended for use in patients younger 18 years.

Dosage

For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, may be taken anywhere from 4 hours to 0.5 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.

Storage

Store Dapoxetine at 77 degrees F (25 degrees C).

Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light.

Do not store in the bathroom. Keep out of the reach of children and away from pets.