Duovir-E Kit

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Duovir-E Kit is used in the treatment of HIV (Human Immunodeficiency Virus) in adults. It contains three different anti-retroviral agents – lamivudine, zidovudine and efavirenz.

How is Duovir-E Kit used?

Each Duovir-E kit contains:

• One yellow tablet containing Efavirenz 600mg
• Two white tablets each containing Lamivudine 150mg + Zidovudine 300mg
• Take one white (Lamivudine + Zidovudine) tablet in the morning.
• Take one yellow (Efavirenz) tablet AND one white tablets (Lamivudine + Zidovudine) at night.
• Taking the yellow tablet on an empty stomach (ie. at bedtime) can decrease potential nervous system side effects.

How Duovir-E Kit works

Lamivudine prevents the multiplication of HIV virus in human cells. Thus stops the HIV virus from producing new viruses.

Adverse effects

The most common side effects associated with Duovir-E are:

• headache
• tiredness
• nausea
• diarrhea
• nasal signs and symptoms
• cough

Less frequently, patients have reported:

• fever
• vomitting
• anorexia / decreased appetite
• abdominal pain and/or cramping
• dyspepsia
• neuropathy
• insomnia / sleep disorders
• dizziness
• depression
• skin rash
• musculoskeletal pain
• myalgia
• arthralgia

Duovir E Kit – Precautions & How to Use

Before using Duovir E Kit, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

• Always taken in combination with other anti-HIV medicines and never alone
• Any signs of skin rash or inflammation or infection
• Avoid driving and operating heavy machinery if you experience dizziness from taking this medication
• Avoid pregnancy
• Children
• Difficulty concentrating or abnormal dreaming

There is a risk of fetal damage if Duovir-E is taking during the first trimester of pregnancy. Only take Duovir-E while pregnant, or if you a planning to become pregnant if the benefit outweighs the potential risks. Discuss this with your doctor

Make sure your doctor is aware of all medicines you are currently taking. Many different drugs can have a negative interaction with the active ingredients in Duovir-E.

Precautions

Duovir-E can result in damage to the fetus if it is taken during the first trimester of pregnancy. Your doctor will be able to outline the potential benefits of treatment and the potential risks. Discuss with them whether you should be taking Duovir-E.

Tell you doctor if you are taking any prescription drugs or over-the-counter medicines. Several of these will have a negative interaction with the active ingredients in Duovir-E, or Duovir-E may prevent them from working properly.

Warnings and Precautions for Duovir E Kit

• Caution should be exercised in patients with history of bone marrow depression, low blood counts, liver, kidney diseases, obesity, any allergy, who are taking other medications, during pregnancy and breastfeeding.
• Avoid contact with people who have infections.
• Avoid sexual contact with your partner in order to avoid transmission of HIV infection.
• Monitor liver, kidney functions, and complete blood cell counts while taking this medication.

Other Precautions for Duovir E Kit

Avoid excess dosage.

Storage Conditions for Duovir E Kit

Store it at room temperature and away from light.

Schedule : H  Prescription drugs – Drugs to be sold only under the prescription of a Registered Medical Practitioner.

Frequently asked questions about Zidovudine

 Is Zidovudine an antibiotic?

No, Zidovudine is not an antibiotic; it belongs to a class of drugs called antiretrovirals

Is Zidovudine a prodrug?

Yes, Zidovudine is a prodrug and must be activated (by phosphorylation in lymphocytes) in the body to exert its antiviral action

Is zidovudine a protease inhibitor?

No, zidovudine is not a protease inhibitor; it is a nucleoside analogue reverse transcriptase inhibitor

How does Zidovudine work?

Zidovudine belongs to a group of medications called nucleoside analogue reverse transcriptase inhibitors (NRTIs), also known as antiretrovirals. Zidovudine does not cure HIV infection; it reduces the amount of viruses in the body by inhibiting the chemical (viral reverse transcriptase) which is essential for the virus to grow. Further, Zidovudine also increases some white blood cells (CD4 cells) of the body that are important in fighting infections.

What is Zidovudine used for?

Zidovudine is used in combination with other antiretroviral medicines for the treatment of human immunodeficiency virus (HIV) infection

How is Zidovudine administered?

Zidovudine can be administered as tablets, syrups and suspension in combination with other antiretroviral medications

Does Zidovudine cause muscle pain?

Yes, muscle pain is a known adverse effect of use Zidovudine

Does Zidovudine cause lipodystrophy?

There are no known effects of Zidovudine on lipid distribution and it is not known to cause lipodystrophy

How does Zidovudine cause anemia?

Zidovudine is known to cause bone marrow depression and thereby cause anemia (reduction in red blood cell count)

How much does Zidovudine cost?

The price of Zidovudine may vary depending upon the brand prescribed to you.Please read the instruction on the package for the correct price of the product.