Buy Duovir N Online
Duovir-N Tablets are a combination of three drugs namely zidovudine, lamivudine and Nevirapine that are commonly used in the management of the Human Immunodeficiency Virus (HIV) infection. Zidovudine and lamivudine belong to the nucleoside analogue class of antiretroviral drugs which act by terminating the growth of the DNA chain and inhibiting the reverse transcriptase (RT) of HIV. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It acts by directly inhibiting Reverse Transcriptase.
The active ingredients contained in Duovir-N Tablets is zidovudine, lamivudine and Nevirapine.
Uses of the drug:
This medicine is used for HIV infections. HIV is Human Immunodeficiency Virus; this virus is responsible for spreading AIDS disease. HIV can be transmitted through blood transfusion, mother to child during pregnancy and through sexual contact with infected persons etc.
Working of the drug:
Lamivudine and Zidovudine inhibits reverse transcriptase of HIV and prevents the proper transcription of the viral DNA. They both inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The chain elongation process is inhibited and finally the viral DNA growth is inhibited. The NNRTIs or Nevirapine attach to and block the HIV enzyme called reverse transcriptase.
Manufacturer:Duovir N 150 +300 mg is manufactured by Cipla, India. You can buy Duovir N 150+300 mg online at Strapcart.com.
Dosage and Administration
Duovir N (Lamivudine/Zidovudine/Nevirapine) film coated tablets contain 150mg of lamivudine, 300mg of zidovudine and 200mg of nevirapine. Administration is by means of the oral route. However, due to the risk of serious and potentially fatal skin reactions, your doctor will recommend a 2 week period (called a lead in dose) in which the active ingredients are administered separately in accordance with the instructions of your doctor.
If your doctor is satisfied that nevirapine is well tolerated, you may then be told to take this medicine. Doctors generally tell patients to take one tablet twice per day (only after the lead in period). In all cases, you must do exactly as your doctor tells you, and never exceed the recommended dosage.
Before you take this drug:
- Do not take this drug if you:
- Are allergic to this drug or any of the other ingredients of this medicine
- Are pregnant, take all the medicine for HIV prescribed by the doctor, to prevent the spread of HIV to the unborn baby.
- Are breastfeeding or planning to breast feed
- Have very low WBC/ RBC count
Tell your doctor if you:
- Have kidney problems
- Have liver abnormalities
- Have problem related to pancreas
- Have nervous system abnormalities
- Have muscle related problems
Duovir-N – Contraindications
Duovir-N Tablets are contraindicated in patients with previously demonstrated clinically significant hypersensitivity (eg, anaphylaxis, Stevens-Johnson syndrome) to zidovudine, lamivudine and Nevirapine or any inactive components of the product. It is also contraindicated in patients with moderate or severe (Childs Pugh Class B or C, respectively) hepatic impairment.
How should Zidovudine be used:
It comes as a capsule and syrup to take by mouth, with or without food. Adult- PO- The recommended dose is 600mgday in divided doses.
Common side effects of Zidovudine :
Headache. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Not hungry. Anemia and low white blood cell count.
What do I do if I miss a dose
Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.
What precautions should I take when taking Zidovudine :
If you have an allergy to zidovudine or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
Side Effects Of Duovir-N
The most common side effects of Duovir-N are
Body as a Whole
Headache ,Malaise and fatigue, Fever or chills
Nausea, Diarrhea, Nausea and vomiting, Anorexia and/or decreased appetite, Abdominal pain, Abdominal cramps, Dyspepsia
Things to remember:
- This drug will not keep you from spreading HIV to others so, take the necessary precautions
- The serious effects of this drug mostly occur in women and obese people
- Tell the doctor immediately if the liver problems worsens
- Keep regular contact with your doctor in case of emergency
- Patients should never miss the dose as it’s a part of combination therapy