Buy Estramustine 140mg
Estramustine phosphate sodium, an antineoplastic agent, is an off-white powder readily soluble in water. EMCYT Capsules are white and opaque, each containing estramustine phosphate sodium as the disodium salt monohydrate equivalent to 140 mg estramustine phosphate, for oral administration. Each capsule also contains magnesium stearate, silicon dioxide, sodium lauryl sulfate, and talc. Gelatin capsule shells contain the following pigment: titanium dioxide.
Estramustine 140mg Composition
Estramustine 140mg How To Work
Estramustine is a combination of oestradiol and normustine which readily dephosphorylates during absorption to give estramustine, oestrone analog, oestradiol and oestrone. The oestrodiols released facilitate the uptake of the alkylating agent Into the prostate cancer cells which Inhibits microtubule assembly. Its effects are weaker than most alkylating agents and oestradiols.
What Is Estramustine 140mg
Estramustine is a complex of 17-beta-estradiol and nornitrogen mustard linked by a carbamate ester bridge therefore, it has both cytotoxic and antigonadotropic effects.
Estramustine sodium phosphate is a pro-drug. After oral administration, it is rapidly converted to estramustine, most of which is oxidized to another cytotoxic metabolite, estromustine. Estramustine and estromustine exert their cytotoxic effect by binding to tubulin and/or microtubuleassociated proteins, inducing depolymerization and cellular metaphase arrest.
Estramustine 140mg How To Take
Take this medication by mouth on an empty stomach, either 1 hour before or 2 hours after a meal, usually 3-4 times a day or as directed by your doctor.Take this medication with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise.Take this medication regularly in order to get the most benefit from it.
Remember to take it at the same times each day as directed. The dosage is based on your medical condition, weight, and response to therapy.Take this medication 3 hours before or after taking any products containing magnesium, aluminum, or calcium. Some examples include quinapril, didanosine, vitamins/minerals, and antacids. Dairy products (e.g., milk, yogurt), calcium-enriched juice, sucralfate, bismuth subsalicylate, iron, and zinc are also included.
These products bind with estramustine, preventing its full absorption.Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.Since this drug can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.
Estramustine 140mg Drug Interactions
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
This drug should not be used with the following medications because very serious interactions may occur: aromatase inhibitors (e.g., anastrozole, exemestane), troleandomycin, tranexamic acid.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting this medication.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: corticosteroids (e.g., prednisolone), ospemifene, tamoxifen, medication for low thyroid (hypothyroidism).Certain drugs can affect the estrogen levels in your system.
Drugs that may cause this effect include: azole antifungals (e.g., itraconazole, ketoconazole), many antibiotics (e.g., cephalosporins, chloramphenicol, macrolides, penicillins, tetracyclines, sulfas), aprepitant, bexarotene, bosentan, dapsone, griseofulvin, certain HIV protease inhibitors (e.g., nelfinavir, ritonavir), modafinil, nevirapine, rifamycins (e.g., rifampin), many seizure medications (e.g., barbiturates, carbamazepine, phenytoin, primidone, topiramate).
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
Estramustine 140mg Side Effects
- breast tenderness
- decreased interest in sex
- decreased sexual ability
- muscle weakness
- stomach upset
Estramustine 140mg Warning
Do not smoke cigarettes or use tobacco. Estrogens combined with smoking further increase your risk for stroke, blood clots, high blood pressure, and heart attacks.If you will be having surgery or will be confined to a chair or bed for a long time (e.g., a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking this drug because of the increased risk for blood clots.
If you have diabetes, estramustine may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor.If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur.This medication may cause blotchy, dark areas on your face and skin (melasma).
Estramustine 140mg Precaution
Before taking estramustine, tell your doctor or pharmacist if you are allergic to it; or to estradiol or other estrogens; or to nitrogen mustard (e.g., mechlorethamine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of stroke or other blood clots (e.g., in the legs, eyes, lungs), bone disease (e.g., bone metastases, high calcium levels), high cholesterol or triglyceride (blood fat) levels, depression, diabetes, severe headaches (e.g., migraine), heart disease (e.g., angina, heart attack, heart failure), high blood pressure, kidney disease, liver disease, seizure, long periods of sitting or lying down (e.g., immobility such as being bedridden), stroke, thyroid problems.
Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.This medication may affect the production of sperm. Use a reliable form of birth control while on this medication.
Consult your doctor.This medication is not usually used in women. Therefore, it is unlikely to be used during pregnancy or breast-feeding. Consult your doctor if you have any questions about this medication.
Estramustine 140mg Dosage
- Estramustine 140mg
Estramustine 140mg Safety Information
Do not share this medication with others.Laboratory tests (e.g., blood pressure, liver function tests, calcium levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
Estramustine 140mg Uses
Estramustine medication is used to treat some types of prostate cancer. In the body, estramustine breaks down into estrogens (estrone, estradiol) and a type of cancer drug (estromustine). This medication is thought to work by increasing estrogens, which interfere with prostate cancer, and by slowing/stopping the growth of cancer cells.
Estramustine 140mg Storage
Store the product in the refrigerator between 36-46 degrees F (2-8 degrees C) away from light and moisture. Do not store in the bathroom.Store the Canadian product between 36-77 degrees F (2-25 degrees C) away from light and moisture.
Do not store in the bathroom.Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Estramustine 140mg Review
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