Buy Januvia 50mg Online
Januvia (sitagliptin) is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.
Januvia is for treating people with type 2 diabetes.
How does Januvia work?
Januvia tablets 50mg contain sitagliptin, a potent and selective inhibitor of the enzyme dipeptidyl peptidase 4 (DPP-4) that works by preventing the breakdown of two small proteins called incretins. These incretins are Glucose-dependent Insulinotropic Polypeptide (GIP) is and Glucagon-Like Peptide-1 (GLP-1) and are involved in the regulation of glucose homeostasis (maintaining normal glucose levels). They are released from the intestine in response to increased glucose levels, particularly following food ingestion and stimulate glucose-dependent insulin production from the pancreatic beta cells to lower blood glucose levels; as well as suppressing glucagon release from the pancreatic alpha cells to reduce glucose production in the liver. However, the incretins are normally rapidly degraded by DPP-4 into inactive metabolites. Sitagliptin in Januvia tablets 50mg inhibits this degradation, thereby increasing incretin levels, allowing them to be active for longer so that they can continue to restore blood glucose to normal levels. This process is glucose-dependent and is only activated when glucose levels are raised and therefore, unlike other anti-diabetic medications, does not lead to hypoglycaemia (low blood sugar), which is a potentially serious side effect. Januvia 50 helps reduce hyperglycaemia and restores glycaemic control in patients with T2DM.
When should Januvia not be used?
You should not use Januvia tablets 50mg if you:
- are allergic to sitagliptin or any ingredients in Januvia
- have type 1 diabetes or diabetic ketoacidosis
- have symptoms of pancreatitis while taking Januvia, including severe persistent stomach pain, with or without vomiting
- are pregnant or are breastfeeding
- have severe kidney disease
- are taking medicines that interact with Januvia: digoxin for heart failure is slightly affected by sitagliptin
Januvia (Sitagliptin) should not be used to treat patients who are pregnant, breastfeeding, under the age of eighteen, or who have type 1 diabetes or diabetic ketoacidosis. You are also suggested to inform your doctor if you have severe kidney disease as this condition may cause unexpected health problems requiring special adjustments to your regimen.
Seek immediate emergency medical attention if you suffer an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing.
Always use Januvia (Sitagliptin) as you have been prescribed by your doctor. Never self-medicate or change your dosage without first consulting your doctor. The correct dosage can vary depending on your health, medical history, and the severity of the condition being treated.
Januvia (Sitagliptin) may not be safe for all patients. Before you begin using it always disclose the following to your doctor:
- If you are pregnant or breastfeeding.
- If you suffer from any allergies.
- If you suffer from any other health conditions or illnesses.
- If you are using any other medicine (including all non-prescription).
- If you are using any supplements, vitamins, or herbal products of any kind.
Dosage & Administration
Januvia (Sitagliptin) should always be used strictly according to your doctor’s instructions to get the most effective results from treatment. Most patients are prescribed one tablet daily, but your individual instructions will depend on your age, weight, health condition, and the severity of your symptoms. These should be swallowed with a large glass of water and may be taken on an empty stomach, although a snack or meal is suggested before use if you get an upset stomach. Do not change the form of the tablets prior to use as this may destroy or alter the effects of their contents. Ask your doctor any questions you have about the medication to ensure the correct usage.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
In controlled clinical studies as both monotherapy and combination therapy with metformin, pioglitazone, or rosiglitazone and metformin, the overall incidence of adverse reactions, hypoglycemia, and discontinuation of therapy due to clinical adverse reactions with JANUVIA were similar to placebo. In combination with glimepiride, with or without metformin, the overall incidence of clinical adverse reactions with JANUVIA was higher than with placebo, in part related to a higher incidence of hypoglycemia (see Table 3); the incidence of discontinuation due to clinical adverse reactions was similar to placebo.
Two placebo-controlled monotherapy studies, one of 18-and one of 24-week duration, included patients treated with JANUVIA 100 mg daily, JANUVIA 200 mg daily, and placebo. Five placebo-controlled add-on combination therapy studies were also conducted: one with metformin; one with pioglitazone; one with metformin and rosiglitazone; one with glimepiride (with or without metformin); and one with insulin (with or without metformin). In these trials, patients with inadequate glycemic control on a stable dose of the background therapy were randomized to add-on therapy with JANUVIA 100 mg daily or placebo. The adverse reactions, excluding hypoglycemia, reported regardless of investigator assessment of causality in ≥5% of patients treated with JANUVIA 100 mg daily and more commonly than in patients treated with placebo, are shown in Table 1 for the clinical trials of at least 18 weeks duration.
Always take Januvia exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
The usual dose is:
- one 100 mg film-coated tablet
- once a day
- by mouth
Your doctor may prescribe Januvia alone or with certain other medicines that lower blood sugar.
Continue to take Januvia as long as your doctor prescribes it so you can continue to help control your blood sugar.
Diet and exercise can help your body use its blood sugar better. It is important to stay on the diet, exercise and weight loss program recommended by your doctor while taking Januvia.
You should store your Januvia below 30°C in a cool dry place.
Keep out of the reach and sight of children.
Do not use Januvia after the expiry date which is stated on the blister and the carton. The expiry date refers to the last day of that month.
This medicine does not require any special storage conditions.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.