Buy Lopimune Tablets Online
The generic version of Lopinavir & Ritonavir 200 mg/ 50 mg mg contains the same active ingredients as the original brand name drug, and is as just as effective. CanadaDrugsOnline.com provides generic Lopinavir & Ritonavir 200 mg/ 50 mg mg tablets which meet the quality and safety standards to ensure your health. Generic Lopinavir & Ritonavir is also Lopimune made by Cipla in India. Lopinavir & Ritonavir is a fixed dose combination treatment for:
- Human Immunodeficiency Virus (HIV) infection in adults over and children over 6 months.
Lopinavir and Ritonavir are antiretroviral agents that fall into the category of drugs known as protease inhibitors. Both the drugs interfere with the virus reproduction to fight HIV or human immunodeficiency virus. The medication does not cure AIDS or destroy the virus. It only helps in preventing further damage by slowing down the progression of the disease. Also, the combination drug is not capable of reducing the risk of passing the infections on to others. A sufferer is still able to transfer the virus through sexual contact, sharing needles, or by blood transfer. Therefore, it is recommended to use precautionary measures to prevent passing HIV on to others.
What is Lopimune used for?
Lopimune tablets 200/50mg are a fixed dose combination treatment for Human Immunodeficiency Virus (HIV) infection in adults over and children over 6 months. Lopimune tablets200/50mg are used in combination with other medications that have a different mechanism of action to the components in Lopimune, and are used to treat patients with HIV infection who have either already received treatment with other medications for HIV or as first line therapy for treatment-inexperienced patients. HIV impairs the immune system by attacking specific immune cells called CD4+ cells that are involved in fighting infection and this can lead to opportunistic life-threatening infection (infections that would not normally be harmful); also if too many CD4+ cells are destroyed this can result in acquired immune deficiency syndrome (AIDS). Lopimune tablets prevent or slow down the ability of HIV to replicate and spread, which keeps the amount virus down to a low level and this results in an increase in CD4+ cell numbers, so that the immune system can recover, reducing the risk of disease progression.
How does Lopimune work?
Lopimune tablets 200/50mg contain lopinavir and ritonavir, which are both inhibitors of HIV protease and are only effective against RNA viruses (retroviruses) like Human Immunodeficiency Virus (HIV). Retroviruses convert RNA to DNA, by the action of the viral-specific enzyme reverse transcriptase (RT). The viral DNA is then integrated into the DNA of infected immune cells so that the virus can replicate. Most of the antiviral activity of Lopimune is due to lopinavir, which is a potent inhibitor of HIV protease, and prevents cleavage of the Gag-Pol polyprotein, an important protein in the development of active virus. The viral protease enzyme cleaves (breaks down) the Gag-Pol polyprotein during final stages of the replication cycle so that fully active mature virus can be released to infect new cells. Inhibition of protease cleavage by Lopimune results in the production of immature, non-infectious viral particles. Ritonavir in Lopimune tablets 200/50mg is included in the combination not as a protease inhibitor but because it inhibits the CYP3A-mediated metabolism (breakdown in the liver) of lopinavir, thereby increasing the plasma levels of lopinavir so that lopinavir can be used at a lower dose. Lopimune tablets are used in combination with other retrovirals that have a different mechanism of action, like emtricitabine and tenofovir, both nucleoside reverse transcriptase inhibitor (NRTI) that work by blocking the action of RT, inhibiting viral replication. The combined action of lopinavir and ritonavir in Lopimune tablets 200/50mg, in conjunction with other retroviral drugs, inhibits the production of active HIV so that the viral load (amount of virus) is reduced. Lopimune tablets slow down the replication of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others.
Before you take the drug:
Do not take the drug if you:
- Are pregnant or breastfeeding
- Have liver problems
- Are hypersensitive towards Lopinavir, Ritonavir, or other inactive ingredients of the medicine
- Tell your doctor if you:
- Have hemophilia
- A history of hepatic impairment
- Diabetes mellitus
- Have known alcohol intolerance
- A history of hepatitis
- Ischemic heart disease
How much to take the drug?
The usual adult dose is two to three tablets twice daily. Take only as prescribed by your doctor. The combination medication can be taken with or without food. In case of stomach issues, you can take the tablet with food to avoid any problem. Do not crush or chew the tablet; it should be swallowed with water.
How long to take it?
Continue taking this antiretroviral medication for as long as your doctor tells you. The medicine is not a cure for HIV infection; it only controls the virus. Note that you will continue to develop infections or other infections associated with HIV during the treatment with Lopimune. Do not even try to change the daily dose of the drug without first discussing with your doctor. You should always take medicine to control the progression of HIV, no matter how much better you feel.
Immediately call your doctor for advice, or go to the nearest hospital if you have taken too many Lopimune tablets. Users are advised to do this even they do not develop any signs of overdose. It is necessary to take urgent medical help to avoid any further problem.
If you forget to take the dose and it is almost time to take the next dose, skip the missed dose and take the next dose on time. Otherwise, take it when you remember and follow your normal dosing schedule. Always keep in mind that taking double dose will only cause side effects. Hence, avoid taking two doses at the same time to compensate the missed dose. If you have any doubt regarding the missed dose, please talk to your doctor.
What are the adverse effects of Lopimune 200 mg/50 mg Tablets ?
Lopimune may cause some side effects. Medicines and their possible side effects can affect individual people in different ways. Side-effects may vary for each individual depending on the person’s disease state, age, weight, gender, ethnicity and general health. The following are some of the side effects that are known to be associated with Lopinavir & Ritonavir :
Common Side Effects of Lopimune Tablets :
Headache ; Dizziness ; Anxiety ; Insomnia ; Decreased appetite and weight loss ; Increase in the level of cholesterol and triglycerides in the blood ; Muscle weakness or spasms ; Chest infections ; Increased blood pressure ; Digestive symptoms such as abdominal pain or bloating, wind, indigestion or heartburn etc.
Serious Side Effects of Lopimune Tablets :
Stroke or heart attack ; Kidney problems such as kidney inflammation ; Blood in the urine ; Rectal bleeding ; Constipation ; Problems with vision ; Blood clot in a vein of the leg ; Hair loss (alopecia) ; Muscle breakdown (rhabdomyolysis) etc.
The side effects listed above may not include all of the side effects. For more information about any other possible risks associated with Lopimune, please read the information provided with the medicine or consult your doctor or pharmacist.
Expert advice for Ritonavir
- Consult your doctor about taking the ritonavir if you had a history of hepatitis A or B, hemophilia, diabetes, erectile dysfunction, kidney disease, any kind of infection, stiffness or aches or pains in joints, weakness or pain or tenderness in muscles, light-headedness, dizziness, fainting episodes or abnormal heartbeat.
- Ritonavir tablets should always be taken with food.
- Use effective methods of contraception to avoid pregnancy.
- Do not drive or operate machinery as ritonavir can cause dizziness or sleepiness.
Frequently asked questions about Ritonavir
What is Ritonavir used for?
It is used along with other medication for treating human immunodeficiency virus (HIV) infection. It does not completely cure HIV or AIDS
Why is ritonavir used along with lopinavir?
Ritonavir is available with lopinavir as a fixed dose combination as it improves the availability of lopinavir which helps in increasing activity against HIV
Is ritonavir a protease inhibitor?
Ritonavir, a protease inhibitor
How does Ritonavir work and what does it inhibit?
Ritonavir belongs to a class of medication called protease inhibitors. It inhibits protease enzymes from breaking down proteins and thus prevents HIV from multiplying inside the body. It does not cure HIV completely but reduces the chances of getting acquired immunodeficiency syndrome (AIDS) and HIV related infections or cancer
Why is it used as a booster?
Ritonavir is used as a booster to increase the absorption of other protease inhibitors as well as prevent other protease inhibitors from being degraded.