Buy Minirin 0.1mg Online
Minirin 0.1mg Tablet have the same structure as that of the natural hormone vasopressin. Vasopressin lowers the amount of urine and bleeding by constricting (narrowing) the blood vessels which, in turn, prevents the loss of water from the body.
Minirin tablets 0.1mg contain desmopressin, a synthetic analogue of arginine vasopressin (AVP), the natural (endogenous) antidiuretic hormone (ADH) that is used to treat conditions characterised by polyuria (production of large amounts of urine and/or excessive urination) to reduce urine production.
How does Minirin work?
Minirin tablets 0.1mg contain desmopressin, a synthetic structural analogue of arginine vasopressin (AVP) that is used to reduce urine production in conditions where there is over production of urine due to a lack of the endogenous (naturally produced) antidiuretic hormone. Desmopressin has increased potency and stability compared to AVP, but does not have the pressor effects of AVP, which means that it does not increase blood pressure. AVP acts directly on the tubules of the kidney at the distal portion of the nephron, which is the functional unit of the kidney, at the collecting duct where the water and salt concentration of the urine is regulated. Binding of AVP to specific cell surface receptors (AV2) in the nephron, triggers a membrane bound enzyme, adenylate cyclase to produce cAMP (cyclic adenosine monophosphate), which activates an intracellular signal transduction mechanism to open water channels (aquaporins) through which water is reabsorbed from the urine back into the blood. Desmopressin in Minirin tablets 0.1mg binds potently and selectively to the AV2 receptors to promote water absorption from the urine back into the blood, which reduces urine volume and is effective for between 6 and 14 hours. Minirin tablets 0.1mg are effective in treating symptoms associated with over production of urine (polyuria) in DI, primary nocturnal enuresis and nocturia.
When should Minirin not be used?
You should not use Minirin tablets 0.1mg if you:
- are allergic to desmopressin, AVP or any ingredients in Minirin
- are pregnant or are breastfeeding, without discussion with your doctor
- have kidney disease
- drink large amounts of fluid
- known hyponatraemia (low blood sodium)
- have syndrome of inappropriate ADH secretion (SIADH) which causes excessive release of ADH
- cardiac insufficiency (heart failure) or other conditions requiring treatment with diuretics
- are taking medicines that interact with Minirin including tricyclic and SSRI antidepressants, anticonvulsants like carbamazepine, antipsychotics like chlorpromazine, sulfonylurea antidiabetic medications like chlorpropamide, NSAIDs for pain and inflammation, loperamide for diarrhoea.
Several medications interact with Minirin tablets 0.1mg and should either not be taken while you are taking Minirin or only after discussion and instruction from your doctor:
- Drugs that cause a serious reaction with Minirin: tricyclic and SSRI antidepressants; anticonvulsants like carbamazepine, antipsychotics like chlorpromazine, sulfonylurea antidiabetic medications like chlorpropamide, can induce release of ADH (SIADH); NSAIDs for pain and inflammation, loperamide for diarrhoea can increase risk of water retention and hyponatremia
- Drugs that affect Minirin: loperamide for diarrhoea
Initial dose: 0.05 mg orally twice a day or
1 to 2 mcg IV twice a day or
1 to 2 mcg subcutaneously twice a day or
5 to 40 mcg spray intranasally twice a day or
0.1 to 0.4 mL via rhinal tube intranasally twice a day.
The optimal dosage depends on the patient’s response (duration of sleep and adequate, not excessive water turnover). The morning and evening doses should be separately adjusted for an adequate diurnal rhythm of water turnover.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- flushing or redness of skin
- nasal congestion
- runny nose
- stomach cramps
- upset stomach (nausea)
Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- headache (continuing)
- weight gain
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Precautions & Warnings
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
- Blood pressure: This medication may occasionally cause increases in blood pressure. If you have high blood pressure or heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed
- Cystic fibrosis: People with cystic fibrosis are more likely to experience low levels of sodium in the body. This can lead to increased side effects with desmopressin. If you have cystic fibrosis, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
- Fluid and electrolyte balance: Fluid intake should be adjusted in order to reduce the possibility of water retention and low levels of sodium in the blood, especially for very young people and for seniors. People who are dehydrated should wait until their water balance has been adequately restored before taking desmopressin. Seniors should be closely observed for possible water retention and low sodium in the blood due to excessive fluid intake. Talk to your doctor about adjusting the amount of fluid intake that is right for you. For control of nighttime urination, a restricted fluid intake is recommended a few hours before using this medication.
- Lactose intolerance: The regular tablet form of this medication contains lactose. If you have galactose intolerance (galactosemia, glucose-galactose malabsorption, or Lapp lactase deficiency) you should not take this formulation. The sublingual tablet formulation does not contain lactose.
- Medical conditions: Desmopressin is not effective in controlling excessive urination caused by kidney disease, diabetes, psychosomatic conditions, low blood potassium, or high blood calcium.
- Short-term illnesses: Many short-term illnesses such as fever, infections and stomach irritation can cause dehydration. This dehydration may cause complications with the use of desmopressin. Talk to your doctor about how to manage your desmopressin treatment if you develop a short-term illness.
- Tolerance: There are reports of changes in response over time, usually when the medication has been used for periods longer than 6 months. Some people may experience decreased responsiveness, while others may experience a shortened duration of effect.
- Urinary tract problems: If you have severe bladder or voiding problems, the way your body gets rid of excess water or sodium may be impaired. Discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
- Pregnancy: This medication has been used during pregnancy with no harm reported. However, no controlled studies have been done on its use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
- Breast-feeding: It is not known if desmopressin from desmopressin tablets passes into breast milk. If you are a breast-feeding mother and are taking desmopressin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
- Children: Children are more likely to experience low sodium levels and fluid build up as a result of consuming too much fluid. Your child’s doctor should closely monitor fluid and sodium levels while your child is taking desmopressin.
- Seniors: Seniors are more likely to experience low sodium levels and fluid build up as a result of consuming too much fluid or decreased kidney function. Your doctor should closely monitor your condition while you are taking desmopressin.
- Diabetes insipidus
- Von willebrand’s disease