Imbruvica 140mg

Buy Imbruvica 140mg

Imbruvica 140mg (ibrutinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Imbruvica is used to treat certain types of non-Hodgkin lymphoma, including mantle cell lymphoma (MCL), Waldenstrom’s macroglobulinemia, and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) in people with or without 17p deletion.

Imbruvica 140mg is also used to treat marginal cell lymphoma and chronic graft-versus-host disease. It is sometimes given when other medicines have not been effective.

Imbruvica 140mg was approved to treat mantle cell and marginal lymphomas by the US Food and Drug Administration (FDA) on an “accelerated” basis. In clinical studies, some people responded to this medicine, but further studies are needed.

Imbruvica 140mg Composition

• Ibrutinib

Imbruvica 140mg Company Name

• Janssen Pharmaceuticals

Imbruvica 140mg How To Work

Imbruvica 140mg Capsule is a Bruton’s tyrosine kinase inhibitor. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

What Is Imbruvica 140mg

Imbruvica 140mg (ibrutinib) is available as immediate-release oral capsules and immediate-release oral tablets.

Imbruvica 140mg (ibrutinib) capsules for oral administration are available in the following dosage strengths: 70 mg and 140 mg. Each capsule contains ibrutinib (active ingredient) and the following inactive ingredients: croscarmellose sodium, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate. The capsule shell contains gelatin, titanium dioxide, yellow iron oxide (70 mg capsule only), and black ink.

Imbruvica (ibrutinib 140mg) tablets for oral administration are available in the following dosage strengths: 140 mg, 280 mg, 420 mg, and 560 mg. Each tablet contains ibrutinib (active ingredient) and the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and sodium lauryl sulfate. The film coating for each tablet contains ferrosoferric oxide (140 mg, 280 mg, and 420 mg tablets), polyvinyl alcohol, polyethylene glycol, red iron oxide (280 mg and 560 mg tablets), talc, titanium dioxide, and yellow iron oxide (140 mg, 420 mg, and 560 mg tablets).

Imbruvica 140mg How To Take

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.

Mechanism Action Of Imbruvica 140mg

Bruton’s tyrosine kinase (BTK) inhibitor; forms a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity; BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways.

BTK’s role in signaling through the B-cell surface receptors results in activation of pathways necessary for B-cell trafficking, chemotaxis, and adhesion.

Imbruvica 140mg Drug Interactions

Coadministration with a strong or moderate CYP3A inhibitors may increase ibrutinib plasma concentrations and drug-related toxicities

Coadministration with strong CYP3A inducers may decrease ibrutinib concentrations

Avoid grapefruit and Seville oranges during treatment, as these contain moderate CYP3A4 inhibitors

• atazanavir
• bosentan
• carbamazepine
• ciprofloxacin
• clarithromycin
• nefazodone
• nelfinavir
• nevirapine
• nicardipine
• venetoclax
• verapamil

Imbruvica 140mg Side Effects

• bladder pain
• chest pain
• chills
• confusion
• headache
• increased thirst
• irregular heartbeat
• itching
• loss of appetite
• nausea and vomiting
• rapid weight gain
• unusual tiredness or weakness

Imbruvica 140mg Warning

To make sure Imbruvica is safe for you, tell your doctor if you have ever had:

• liver or kidney disease;
• an active infection;
• a bleeding or blood clotting disorder;
• a heart rhythm disorder;
• risk factors for heart disease (such as diabetes, smoking, being overweight, having high blood pressure or high cholesterol)
• surgery; or
• a condition for which you take a blood thinner (warfarin, Coumadin, Jantoven).

Using Imbruvica may increase your risk of developing other types of cancer, such as skin cancer. Ask your doctor about your specific risk.

Ibrutinib can harm an unborn baby. Both men and women using this medicine should use birth control to prevent pregnancy. The use of this medicine by either parent may cause harm to the baby.

Keep using birth control for at least 1 month after your last dose of Imbruvica. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using this medicine.

It is not known whether ibrutinib passes into breast milk. It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

Imbruvica 140mg Precaution

Fatal and non-fatal infection (including bacterial, viral, or fungal) reported; 25-26% of patients had ≥Grade 3; consider prophylaxis according to standard of care in patients who are at increased risk for opportunistic infections; monitor and evaluate patients for fever and infections and treat appropriately

Treatment-emergent Grade 3 or 4 cytopenias including neutropenia (range, 13-29%), thrombocytopenia (range, 5-17%), and anemia (range, 0-13%) based on laboratory measurements occurred in patients with B-cell malignancies treated with single agent ibrutinib; monitor CBC monthly

Fatal and serious cases of renal failure have occurred; treatment-emergent increases in creatinine levels up to 1.5 x ULN occurred in 67% (MCL) and 23% (CLL) and from 1.5-3 x ULN in 9% (MCL) and 4% (CLL); periodically monitor creatinine levels and maintain hydration

Other malignancies (5-14%) reported including carcinomas (1-3%); the most frequent second primary malignancy was nonmelanoma skin cancer (4-11%)

Hypertension reported with a median time to onset of 4.6 months; monitor for new onset hypertension or hypertension that is not adequately controlled after initiating ibrutinib

Tumor lysis syndrome infrequently reported; assess the baseline risk (eg, high tumor burden) and take appropriate precautions

Based on findings in animals, can cause fetal harm when administered to a pregnant woman

Metabolized in the liver; although no clinical trials have been completed in patients with impaired hepatic function, ibrutinib systemic exposure was ~6-fold higher in patients (N=3) with moderate hepatic impairment (Child-Pugh B) compared to healthy volunteers

Imbruvica 140mg Dosage

• Imbruvica 140mg

Imbruvica 140mg Uses

Imbruvica 140 mg Capsule is used in the treatment of mantle-cell lymphoma and blood cancer (Chronic lymphocytic leukemia). It is also used in chronic lymphocytic leukaemia who have received at least one prior therapy or with 17p deletion.

Imbruvica 140mg Storage

Store at room temperature between 68-77°F (20-25°C)

Keep ibrutinib in the original container with the lid tightly closed

Imbruvica 140mg Review

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